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Press release

X-ray technology improves early detection of pulmonary disease:

Scattered X-rays reveal diseased tissue

A combination of dark-field and conventional transmission information allows for a clear distinction of healthy versus emphysematous tissue and an assessment of the regional distribution of the disease. From such images, a doctor might in future not only see if a patient is diseased but also which parts of the lung are affected and how much. Picture: Simone Schleede / TUM
A combination of dark-field and conventional transmission information allows for a clear distinction of healthy versus emphysematous tissue and an assessment of the regional distribution of the disease. Picture: Simone Schleede / TUM

Research news

Severe lung diseases are among the leading causes of death worldwide. To date they have been difficult to diagnose at an early stage. Within an international collaboration scientists from Munich now developed an X-ray technology to do just that. Now they are working on bringing the procedure into medical practice.

Chronic obstructive pulmonary disease (COPD) is considered the fourth most common cause of death in the United States. Usually the precursor to this life-threatening lung disease is a chronic bronchitis. Partially destroyed alveoli and an over-inflation of the lungs, known as emphysema, are serious side effects. However, the subtle differences in the tissue are barely discernable in standard X-ray images.

In addition to the conventional X-ray images, the Munich scientists analyzed the radiation scattered by the tissue. From these data they calculated detailed images of the lungs of the investigated mice. Using such images, physicians can see not only if a patient is diseased but also how strongly which parts of the lung are affected.