Multigene testing as a useful decision making tool in breast cancer treatment

Multigene test facilitates targeted use of chemotherapy in breast cancer patients

A doctor checking a patient's breast for lumps.
A doctor checking a patient's breast for lumps: For patients with certain forms of breast cancer, mulitgene tests can provide information on the risk of metastasis. (image: LuminaStock /iStockphoto.com)

Research news

Multigene tests have been used in breast cancer treatment to assess the risk of metastasis for several years. A team at the Breast Cancer Center at the Technical University of Munich’s (TUM) Klinikum rechts der Isar has now presented results based on data collected in its routine clinical work. These results show that the multigene test used at the university hospital is indeed helpful in making more targeted use of chemotherapy treatments and thus improves prognosis of breast cancer patients.

Since November 2011, the Gynecological Clinic at Klinikum rechts der Isar has used a multigene test for patients with early hormone receptor-positive, HER2-negative breast cancer. Using tissue samples and other clinical indicators, the test helps to determine a patient's risk of metastasis. "Based on the test results, which combine molecularbiological properties of the tumor along with the individual factors of tumor size and the presence of cancer in lymph nodes, doctors decide whether chemotherapy is recommended in addition to the surgical removal of the tumor followed by anti-hormone treatment," explains Prof. Marion Kiechle, the Director of the Gynecological Clinic. "In case of a low metastasis risk, chemotherapy may place an unnecessary burden on the patient. But in case of a high risk, it may prevent tumors from relapsing later."

At the San Antonio Breast Cancer Symposium in the USA, one of the world's most important congresses in that field, Dr. Johannes Ettl, Head Physician of the Gyneco-Oncological Outpatient Clinic, Technical University of Munich, Germany has now presented the results of an independent study not commissioned by a test manufacturer of the test used at the Breast Center.

373 patients tested

For the study, Dr. Ettl and his team tracked 373 breast cancer patients from the start of initial treatment and the related multigene test. The test indicated a low risk for 238 patients (63.8%) and a high risk for 135 (36.2%). After a median follow up of 3.5 years, the risk for disease recurrence was twice as high in the high-risk group as in the low-risk group. Similarly, high risk patients were at five-fold increased risk of developing metastases in other organs. The low-risk and high-risk patients who received chemotherapy in addition to anti-hormone tablets had three-year disease free survival rates of 96.6% and 96.3%, respectively. By contrast, for high-risk patients who did not receive chemotherapy despite the doctors' recommendation based on the test results, the rate was only 91.5%.


"Our health care study has delivered the first data from routine clinical practice indicating that the test does, in fact, provide useful input when deciding on chemotherapy," says Prof. Kiechle. "Gene signature tests are important tools that help us to make more targeted use of chemotherapy treatments, both by limiting unnecessarily stressful treatments and avoiding the potentially serious consequences of rejecting chemotherapy in case of high metastasis risks."

Study Abstract on the conference Website:

https://www.abstracts2view.com/sabcs18/view.php?nu=SABCS18L_1275&terms

More Information:

The subject of the investigation was the EndoPredict test, one of the four most commonly used multigene tests in Germany. When it was introduced in 2011, it was the first test that covered gene signatures as well as conventional clinical parameters such as tumor size and the presence of cancer in the lymph nodes.

Contact:

Prof. Dr. Marion Kiechle
Technical University of Munich
Chair of Gynaecology
Tel: +49 89-41402420
marion.kiechle@tum.de