TUM – Technical University of Munich Menu
Fasern des Muskelproteins Aktin
Wie verhalten sich die Grundbausteine des Lebens? Das will das neue Proteinforschungszentrum untersuchen. Im Bild: Fasern des Muskelproteins Aktin. (Bild: Lehrstuhl für Zelluläre Biophysik / TUM)
  • Research news

Federal and Bavarian Government earmark 40 million euros for new building on the Garching Campus

TU München establishes center for protein research

Technische Universität München (TUM) is establishing the “TUM Center for Functional Protein Assemblies (CPA)” to concentrate its wide-ranging expertise in protein research. It will conduct cross-departmental research into the functionalities and mechanisms of action of proteins – a key to understanding cells, tissues, and organs. On this basis, the interdisciplinary Center will develop biomedical applications, for example to treat diseases caused by malfunctions in the interplay between biomolecules. The Joint Science Conference (GWK) decided today that the German Federal Government and the State of Bavaria will fund the new CPA building on the Garching Campus to the tune of 40 million euros.

The "TUM Center for Functional Protein Assemblies" will unite the competences of TUM in protein chemistry, structural elucidation, chemical biology, single-molecule biophysics, cellular biophysics, DNA nanotechnology, molecular dynamics simulation, and bioengineering in a ca. 4,000 square meter building complex in order to fully exploit the methodological and technological potentials available. New appointments will strengthen the fields of biomedical engineering and biomolecular systems engineering.

In its assessment, the German Council of Science and Humanities cited this particularly close-knit interplay of the various scientific disciplines and engineering sciences, as well as the planned transfer of research findings to medical applications. The Center will serve as a beacon for Europe as a whole. TUM ranks among the preeminent institutions in the field of protein research. It is a key player in the "Center for Integrated Protein Science Munich (CIPSM)". The new Magnetic Resonance Center, a further new building in Garching where a world-class 1.2 gigahertz spectrometer will soon be built, will extend the range of available methodologies.

Protein interactions lead to complex dynamics

The human cell consists of a complex ensemble of biomolecules whose interactions make life possible. Malfunctions in this interplay can lead to diseases. To understand tissues and organs and to be able to cure such diseases, it is essential to understand the operation principles of cells.

Among the cellular biomolecules, proteins make up a highly diverse class whose functions range from structure formation (cytoskeleton) to biomolecular catalysis (enzymes). However, proteins rarely perform their functions in isolation. Rather, cellular processes are based on the fact that a large number of synchronized protein interactions lead to new phenomena that go well beyond the functionality of the individual molecules and cannot be derived from individual interactions. For this reason, scientists speak of protein assemblies.

The new Center will study these dynamic protein interactions and the resulting functions. In particular, it will focus on protein interactions in conjunction with protein-folding processes, the formation of structures in the cytoskeletal system, and active-substance pathways. The aim of the interdisciplinary approach is to shed light on the complexity of biological systems, identify their molecular and supramolecular mechanisms of action, and develop (bio)medical applications on this basis.

Prof. Andreas Bausch
Chair of Cell Biophysics
Tel: +49 89 289 12480   

Prof. Stephan Sieber
Chair of Organic Chemistry

Corporate Communications Center

Technical University of Munich

Article at tum.de

[Translate to en:]

Chaperones keep the tumor suppressor protein p53 in check

The anti tumor protein p53 can decide on the life or death of a cell: If it detects damage in the cell's genome, the protein pushes the cell to suicide. New research conducted at Technical University of Munich (TUM) shows...

Von links: Prof. Sami Haddadin und Prof. Brenda Schulman.

Leibniz Prizes for Sami Haddadin and Brenda Schulman

The German Research Foundation (DFG) has awarded the Gottfried Wilhelm Leibniz Prize to Sami Haddadin, Professor of Robotics and Systems Intelligence at the Technical University of Munich (TUM), and biochemist Dr. Brenda...

Die neue Honorarprofessorin an der TUM: Brenda Schulman. (Bild: Peter Barta / BMC, STJUDE)

Brenda Schulman appointed Honorary Professor at the TUM

A high-caliber addition to the faculty of the Technical University of Munich has been announced: the biochemist Dr. Brenda Schulman will serve as Honorary Professor at the TUM. Schulman leads the Molecular Machines and...

Richtfest zum Neubau des Protein-Forschungszentrums auf dem Campus in Garching: Prof. Stephan Sieber, stv. Leiter des Zentrums, Thomas Rachel, MdB, Parlamentarischer Staatssekretär im Bundesministerium für Bildung und Forschung, Alfons Kraft zweiter Bürgermeister der Stadt Garching, TU-Präsident Wolfgang A. Herrmann und Ilse Aigner, bayerische Staatsministerin für Wohnen, Bau und Verkehr (v.l.n.r.). (Foto: A. Heddergott)

Top-notch protein research

With the construction of the new protein research center in Garching, the Technical University of Munich (TUM) is strengthening its biomedical research.  At the topping-out ceremony on August 30, 2018, TUM President...

Das Protein (blau) erkennt die pri-miR18a (pink) und formt deren Struktur zur fertigen miRNA. (Bild: H. Kooshapur / TUM)

New Insights into the Maturation of miRNAs

An international research team has used a structural biological approach to elucidate the maturation of a cancer-causing microRNA in gene regulation. In the future, the authors hope to develop new therapies based on their...

Wellenmuster und Ameisenstraßen können unter denselben Ausgangsbedingungen entstehen und dynamisch koexistieren. (Bild: L. Huber / LMU)

Wave fronts and ant trails

Munich physicists have discovered unique patterning phenomena in systems whose parts move actively. Despite identical initial conditions, two different states can coexist and dynamically interconvert. Their findings provide...

Spatenstich für den Neubau der Fakultät. Von links: TUM-Kanzler Albert Berger, Dr. Dietmar Gruchmann,  Bürgermeister der Stadt Garching, TUM-Präsident Wolfgang A. Herrmann, Wissenschaftsministerin Prof. Marion Kiechle,  Architekt Prof. Gunter Henn, Dr. Georg Freiherr von Waldenfels,  TUM Kuratoriumsvorsitzender und Dekan Prof. Wolfgang Utschick.

New construction for a high-tech department

The beginning of construction for the new Department of Electrical and Computer Engineering building complex coincides with the 150th anniversary of the founding of the Technical University of Munich (TUM). The overall...

Variationen im Genom haben einen stärkeren Effekt als bisher angenommen.

We are much more unique than assumed

Every human being has a unique DNA "fingerprint". In other words, the genetic material of any two individuals can be clearly distinguished. Computational biologists at the Technical University of Munich (TUM) have now...

Leibniz-Preisträger Prof. Franz Pfeiffer und eine Wissenschafterin arbeiten an einem Projekt mit dem Mini-Teilchenbeschleuniger MuCLS.

Munich School of BioEngineering sets European standards

Two years after its founding at the Technical University of Munich (TUM), the Munich School of BioEngineering (MSB) is expanding its scope of action: The upcoming opening of the MSB-associated Central Institute for...

Trypanosomen in der Durchlichtmikroskopie (links) und in der Fluoreszenzmikroskopie (rechts). Angefärbt sind hier die Glykosomen (rot), gegen die sich der Wirkstoff richtet, sowie die DNA des Parasiten (blau). Bild: Ralf Erdmann, Vishal Kalel / Ruhr-Universität Bochum

New therapeutic strategy against sleeping sickness

A newly developed small molecule selectively kills the pathogen causing sleeping sickness and Chagas disease. Scientists from the Technical University of Munich, the Helmholtz Zentrum München and from the Ruhr University...

Wolfgang A. Herrmann, Präsident der TUM (links), mit Clariant-CEO Dr. Hariolf  Kottmann und Susanne Wamsler.

New Award in remembrance of a chemist and patron of the arts

Specialty chemicals company Clariant and the Technical University of Munich (TUM) yesterday signed an agreement covering the joint presentation of a new award: The "Dr. Karl Wamsler Innovation Award" will promote excellent...

Leone Rossetti und Lara Kuntz am Fluoreszenz-Mikroskop (Foto: Andreas Heddergott / TUM)

Unlocking the secrets of the Achilles’ heel

Walking, running, sprinting – every movement of the foot stretches the Achilles’ tendon. When jumping, the loads can approach ten times the body weight. Amazingly, the connection between the heel bone and Achilles’ tendon...

Modell des prämierten Entwurfs  - Foto: Ina Rena Rosenthal

Colored metal panels to encase protein research center

The scientific goal of the new Center for Functional Protein Assemblies (CPA) on the Garching Campus of the Technical University of Munich (TUM) is the interdisciplinary investigation of the functionalities and mechanisms...

TUM-Vizepräsident Hofmann (l) überreicht Prof. Feringa die Ernennungsurkunde zum Honorary Hans Fischer Senior Fellow des TUM-IAS - Bild: Astrid Eckert / TUM

Nobel Prize goes to TUM IAS Fellow Prof. Bernard L. Feringa

Prof. Jean-Pierre Sauvage, Prof. Sir J. Fraser Stoddart and Prof. Bernard L. Feringa have received this year's Nobel Prize in Chemistry for their groundbreaking work on the design and production of molecular machines. Prof....

HUPO-Präsident Professor Mark Baker (l.) überreicht Professor Bernhard Küster vom TUM-Lehrstuhl für Proteomik und Bioanalytik den HUPO Discovery in Proteomic Sciences Award 2015. (Foto: Jon Benjamin)

Professor Bernhard Küster receives HUPO-Award

Professor Bernhard Küster from the Chair of Proteomics and Bioanalytics at the Technische Universität München (TUM) has won this year’s HUPO Discovery in Proteomic Sciences Award for his research on the deciphering of the...

Nicht für alle Proteine ist die dreidimensionale Struktur bekannt.

The "dark matter" in the protein universe

Whether in the form of antibodies, enzymes or carriers: proteins play a crucial role in biology. While researchers have been able to at least partially determine the three-dimensional structure of many proteins, the...

Am TranslaTUM werden interdisziplinäre Teams aus Ingenieuren, Naturwissenschaftlern und Medizinern gemeinsam daran arbeiten, um wissenschaftliche Erkenntnisse rasch in praktische Anwendungen zu „übersetzen“. Diese Translation war namensgebend für das Zentrum. (Bild: doranth post architekten GmbH)

TUM sets the next milestone in biomedicine

Translational cancer research will be the focus of the new TranslaTUM central institute at the Technical University of Munich (TUM). The topping-out ceremony for the new research building (investment volume of approx. EUR...

Grundsteinlegung für den Forschungsneubau des Bayerischen NMR-Zentrums: PStS Stefan Müller (BMBF), Wissenschaftsminister Dr. Ludwig Spaenle, TUM-Präsident Prof. W.A. Herrmann, Prof. Michael Sattler, Leiter des BNMRZ (vlnr) - Foto: Andreas Heddergott / TUM

World-class nuclear magnetic resonance center

The Technical University of Munich (TUM) secures its leading international position in medical protein research with a new large-scale, cutting-edge facility: Today, at the Garching Campus, Bavarian Minister of Science Dr....

Fertigbauprinzip: 32 identische Untereinheiten bilden diese Form des Proteinkomplexes Sip1 – Bild: Tilly Fleckenstein / TUM

A protein provides emergency aid

Small heat shock proteins ensure that other proteins do not clot, allowing the cell to survive stress. Defects in these “small helpers” are associated with medical conditions like cataracts and cancer. Now, scientists at...

Die Webseite "Aquaria" errechnet aufgrund bekannter Daten die dreidimensionale Struktur von Proteinen.

Virtual journey to the innards of proteins

In order to understand diseases and develop medications researchers require information on the three-dimensional structure and function of proteins. The "Aquaria" database provides quick and extensive insight into these...

Forscher der TU München haben bisher umfassendsten Katalog aller Proteine im menschlichen Körper erstellt und in der Datenbank ProteomicsDB veröffentlicht.

Filling in the gaps on the protein map

Substantial progress has been made in decoding the human proteome. Under the leadership of the Technische Universität München (TUM) researchers have now mapped more than 18,000 human proteins – 92 percent of the entire...

NMR/SAXS Strukturmodell des Hsp90-Tau Proteinkomplexes (Hellblau - Hsp90, Orange - Tau) (Bild: Tobias Madl / TUM/HMGU)

Dangerous mistaken identity

Tau proteins, which are responsible for Alzheimer’s disease, bind to the folding protein Hsp90. The molecular recognition mechanisms that play a role here, have been unveiled by an international team of scientists led by...

Nahaufnahme des  aktiven Zentrums von IspH, in dem ein Reaktionspartner gebunden ist. (Bild: TUM)

IspH – a protein free to choose its partners

The iron-sulfur protein IspH plays a central role in the terpene metabolism of several pathogens. The mechanism of the reaction provides an approach for developing new antibiotics, particularly against malaria and...